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A Highly Conserved Neutralizing Epitope on Group 2 Influenza A VirusesEkiert, D. C. et. al.Science, 2011, July 7, Epub ahead of print
Detection of Deoxynivalenol using Biolayer InterferometryMaragos, C. M.Mycotoxin Research, 2011, 27, 157-165
Biosensor-based Small Molecule Fragment Screening with Biolayer InterferometryWartchow, C. A.; Podlaski, F.; Li, S.; Rowan, K.; Zhang, X.; Mark, D.; Huang, K-S.Journal of Computer-aided Molecular Design, DOI: 10.1007/s10822-011-9439-8
Soluble periplasmic production of human granulocyte colony-stimulating factor (G-CSF) in Pseudomonas fluorescensJin, H.; Cantin, G. T.; Maki, S.; Chew, L. C.; Resnick, S. M.; Ngai, J.; Retallack, D. M.Protein Expression and Purification, 2011, 78 (1), 69-77
Chaperone Activity of alpha B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple SclerosisRothbard, J. B.; Zhao, X.; Sharpe, O.; Strohman, M. J.; Kurnellas, M.; Melins, E. D.; Robinson, W. H.; Steinman, L.The Journal of Immunology, 2011, 186 (7), 4263-4268
Structural and Biophysical Analysis of Bst-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus ReleaseSwiecki, M.; Scheaffer, S. M.; Allaire, M.; Fremont, D. H.; Colonna, M.; Brett, T. J.The Journal of Biological Chemistry, 2011, 286, 2987-2997
Role of Iron and Sodium Citrate in Animal Protein-Free CHO Cell Culture Medium on Cell Growth and Monoclonal Antibody ProductionBai, Y.; Wu, C.; Zhao, J.; Liu, Y-H.; Ding, W.; Ling, W. L. W.Biotechnology Progress, 2011, 27 (1), 209-219
Chronic Intranasal Treatment with an Anti-Aâ30-42 scfv Antibody Ameliorates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's DiseaseCattepoel, S.: Hanenberg,M.; Kulic, L.; Nitsch, R. M.PLoS ONE, 2011, 6 (4), e18296
Exploiting Nucleotide Composition to Engineer PromotersGrabherr, M. G. et. al.PLoS ONE, 2011, 6 (5), e20136
The Peroxisomal Targeting Signal 1 in Sterol Carrier Protein 2 is Autonomous and Essential for Receptor RecognitionWilliams, C. P. et. al. BMC Biochemistry, 2011, 12:12
Comparison of an Antibody Capture and a Cell Capture Ligand-Binding Assay to Quantify a Monoclonal Therapeutic in SerumSpriggs, F.; Aggarwal, P.; Deng, S.; Soderstrom, C.; Donovan, C.Bioanalysis, 2011, 3 (6), 605-611
Mutations in the G-H Loop Region of Ephrin-B2 can Enhance Nipah Virus Binding and InfectionYuan, J.; Marsh, G.; Khetawat, D.; Broder, C.; Wang, L.; Shi, Z.Journal of General Virology, 2011, Vir.0.033787-0
TMEFF2 is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including GliomaLin, K. et. al.PLoS ONE, 2011, 6 (4), e18608
Challenges in Developing Bioanalytical Assays for Characterization of Antibody–Drug ConjugatesStephan, J. P. ; Kozak, K. R.; Wong, W. T.Bioanalysis, 2011, 3 (6), 677-700
An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human AntibodyKrause, J. C.; Ekiert, D. C.; Tumpey, T. M.; Smith, P. B.; Wilson, I. A.; Crowe Jr., J. E.mBio, 2011, 2 (1), e00345-10
Lysine Acetylation is a Widespread Protein Modification for Diverse Proteins in ArabidopsisWu, X. et. al.Plant Physiology, 2011, 155 (4), 1769–1778
Robo4 Maintains Vessel Integrity And Inhibits Angiogenesis By Interacting With UNC5BKoch, A. W. et. al.Developmental Cell, 2011, 20 (1), 33-46
Design of a Reversible Biotin Analog and Applications in Protein Labeling, Detection, and IsolationYing, L.; Branchaud, B. P.Chemical Communications, 2011, DOI: 10.1039/c1cc12738a
Divergent Activities Of Osteogenic BMP2, And Tenogenic BMP12 And BMP13 Independent Of Receptor Binding AffinitiesBerasi, S. P. et. al.Growth Factors, 2011, 29 (4), 128-139
Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA OligonucleotideRoh, C.; Kim, S. E.; Jo, S.Sensors, 2011, 11, 6685-6696
Development and Characterization of APRIL Antagonistic Monoclonal Antibodies for Treatment of B-Cell LymphomasGuadagnoli, M. et. al.Blood, 2011, 117, 6856-6865
Role of Iron and Sodium Citrate in Animal Protein-Free CHO Cell Culture Medium on Cell Growth and Monoclonal Antibody ProductionBai, Y. et. al.Biotechnology Progress, 2011, 27 (1), 209-219
Integrin Binding Human Antibody Constant Domains – Probing the C-terminal Structural Loops for Grafting the RGD MotifTraxlmayr, M. W. et. al.Journal of Biotechnology, 2011, doi:10.1016/j.jbiotec.2011.06.042
Review of Transducer Principles for Label-Free Biomolecular Interaction AnalysisNirschl, M.; Reuter, F.; Voros, J.Biosensors, 2011, 1, 70-92
Cytokine Binding by Polysaccharide-Antibody ConjugatesSun, L. T.; Buchholz, K. S.; Lotze, M. T.; Washburn, N. R.Molecular Pharmaceutics, 2010, 7 (5), 1769 – 1777
Generation of Stable Cell Clones Expressing Mixtures of Human AntibodiesDe Kruif, J. and others.Biotechnology and Bioengineering, 2010, 106 (5), 741 – 750
Humanization Strategies for an Anti-idiotypic Antibody Mimicking HIV-1 gp41Mader, A.; Kunert, R.Protein Engineering, Design & Selection, 2010, 23 (12), 947 – 954
Gambogic Acid Inhibits Hsp90 and Deregulates TNF-alpha/NF-kappaB in HeLa CellsZhang, L.; Yi, Y.; Chen, J.; Sun, Y.; Guo, Q.; Zheng, Z.; Song, S.Biochemical and Biophysical Research Communications, 2010, 403, 282 – 287
Autophosphorylation of Tyr-610 in the Receptor Kinase BAK1 Plays a Role in Brassinosteroid Signaling and Basal Defense Gene ExpressionOh, M. –H.; Wang, X.; Wu, X.; Zhao, Y.; Clouse, S. D.; Huber, S. C.Proceedings of the National Academy of Sciences, 2010, Sep. 27, doi: 10.1073/pnas.0915064107
Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met SignalingLandgraf, K. E. and others.Journal of Biological Chemistry, 2010, 285, 40362 – 40372
Specificity for Human Hemoglobin Enhances Staphylococcus aureus InfectionPischany, G.; McCoy, A. L.; Torres, V. J.; Krause, J. C.; Crowe, Jr., J. E.; Fabry, M. E.; Skaar, E. P.Cell Host & Microbe, 2010, 8, 544 – 550
Development and Evaluation of Monoclonal Antibodies against Phosphatidylethanolamine Binding Protein 1 in Pancreatic Cancer PatientsWang, X. and others.Journal of Immunological Methods, 2010, 362, 151 – 160
Detection of Low-Affinity Anti-Drug Antibodies and Improved Drug Tolerance in Immunogenicity Testing by Octet Biolayer InterferometryLi, J.; Schantz, A.; Schwegler, M.; Shankar, G.Journal of Pharmaceutical and Biomedical Analysis, 2011, 54 (2), 286 - 294
Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 AntibodiesGong, Y.; Bourhis, E. and others.PLoS ONE, 2010, 5 (9), e12682
High-throughput Screening and Selection of Yeast Cell Lines Expressing Monoclonal AntibodiesBarnard, G. C. and others.Journal of Industrial Microbiology and Biotechnology, 2010, 37, 961-971
Structural Bases for the Interaction of Frataxin with the Central Components of Iron-Sulphur Cluster AssemblyPrischi, F.; Konarev, P. V.; Iannuzzi, C.; Pastore, C.; Adinolfi, S.; Martin, S. R.; Svergun, D. I.; Pastore, A.Nature Communications, 2010, 1:95, doi: 10.1038/ncomms1097.
Design Principles for Cytokine-Neutralizing Gels: Cross-linking EffectsSun, L. T.; Bencherif, S. A.; Gilbert, T. W.; Lotze, M. T.; Washburn, N. R.Acta Biomaterialia, 2010, 6 (12), 4708 - 4715
Optical Biosensing: Kinetics of Protein A-IgG Binding Using Biolayer InterferometryWilson, J. L.; Scott, I. M.; McMurry, J. L.Biochemistry and Molecular Biology Education, 2010, 38 (6), 400 - 407
Flexible Label-free Quantitative Assay for Antibodies to Influenza Virus HemagglutininsCarney, P. J.; Lipatov, A. S.; Monto, A. S.; Donis, R. O.; Stevens, J.Clinical and Vaccine Immunology, 2010, 17, 1407-1416
GP369, an FGFR2-IIIb Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 SignalingBai, A., and others.Cancer Research, 2010, 70 (19), 7630 - 7639
Direct Transactivator-Transcription Factor IID (TFIID) Contacts Drive Yeast Ribosomal Protein Gene TranscriptionLayer, J. H.; Miller, S. G.; Weil, P. A.Journal of Biological Chemistry, 2010, 285 (20), 15489-15499
Kinetic Characterization of Salmonella FliK-FlhB Interactions Demonstrates Complexity of the Type III Secretion Substrate-Specificity SwitchMorris, D. P.; Roush, E. D.; Thompson, J. W.; Moseley, M. A.; Murphy, J. W.; McMurry, J. L.Biochemistry, 2010, 49 (30), 6386 – 6393
Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory PeptidesCostin, J. M.; Jenwitheesuk, E.; Lok, S. –M.; Hunsperger, E.; Conrads, K. A.; Fontaine, K. A.; Rees, C. R.; Rossmann, M. G.; Isern, S.; Samudrala, R.; Michael, S. F.PLoS Neglected Tropical Diseases, 2010, 4(6): e721
A High-Throughput Purification of Monoclonal Antibodies from Glycoengineered Pichia PastorisJiang, Y.; Li, F.; Button, M.; Cukan, M.; Moore, R.; Sharkey, N.; Li, H.Protein Expression and Purification, 2010, 74 (1), 9 - 15
The Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-Active SiteMaun, H. R.; Wen, X.; Lingel, A.; de Sauvage, F. J.; Lazarus, R. A.; Scales, S. J.; Hymowitz, S. G.Journal of Biological Chemistry, 2010, 285 (34), 26570-26580
A Diversity of Antibody Epitopes Can Induce Signaling Through the Erythropoietin ReceptorLim, A. C.; Ketchem, R. R.; Borges, L.; Carabeo, T.; Carter, J.; Hoover, J. E.; Hu, Z.; Wittekind, M.; Zhou, H.; Mehlin, C.Biochemistry, 2010, 49 (18), 3797-3804
Molecular Basis of FIR-Mediated c-myc Transciptional ControlCukier, C. D.; Hollingworth, D.; Martin, S. R.; Kelly, G.; Diaz-Moreno, I.; Ramos, A.Nature Structural and Molecular Biology, 2010, 17, 1058 - 1064
Surface Plasmon Resonance for Vaccine Design and Efficacy Studies: Recent Applications and Future TrendsHearty, S.; Conroy, P. J.; Ayyar, B. V.; Byrne, B.; O’Kennedy, R.Expert Review of Vaccines, 2010, 9 (6), 645 – 664
Unwanted Immunogenicity: Lessons Learned and Future ChallengesWadhwa, M. and Thorpe, R.Bioanalysis, 2010, 2 (6), 1073 – 1084
Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid beta-related Behavioral Deficits in a Mouse Model of Alzheimer DiseaseBasi, G.S. and others.Journal of Biological Chemistry, 2010, 285, 3417-3427
Neutralizing and Non-neutralizing Monoclonal Antibodies Against Dengue Virus E Protein Dervied from a Naturally Infected Patient.Schieffelin, J.S.; Costin, J. M.; Nicholson, C. O.; Orgeron, N. M.; Fontaine, K. A.; Isern, S.; Michael, S. F.; Robinson, J. E.Virology Journal, 2010, 7, 28-38
Reconstitution of a Frizzled8-Wnt3a-LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.Bourhis, E.; Tam, C.; Franke, Y.; Bazan, J. F.; Ernst, J.; Hwang, J.; Costa, M.; Cochran, A. G.; Hannoush, R. N.Journal of Biological Chemistry, 2010, 285 (12), 9172-9179
Molecular Mechanism of the Synaptotagmin-SNARE Interaction in Ca2+-Triggered Vesicle Fusion.Vrljic, M.; Strop, P.; Ernst, J. A.; Sutton, R. B.; Chu, S.; Brunger, A. T.Nature Structural and Molecular Biology, 2010, 17, 325-331
Rapid Identification of Production StrainsKumaraswamy, S.; Allen, J. R.Genetic and Engineering News, 2010, June 15, 30 (12)
Recombinant Respiratory Syncytial Virus F Protein Expression is Hindered by Inefficient Nuclear Export and mRNA ProcessingHuang, K.; Lawlor, H.; Tang, R.; MacGill, R. S.; Ulbrandt, N. D.; Wu, H.Virus Genes, 2010, 40 (2), 212-221
Human Framework Adaptation of a Mouse Anti-Human IL-13 AntibodyFransson, J. and others.Journal of Molecular Biology, 2010, 398 (2), 214-231
Grading the Commercial Optical Biosensor Literature - Class of 2008: The Mighty BindersRich, R. L.; Myszka, D. G.Journal of Molecular Recognition, 2010, 23, 1-64
Binding Rate Screen - A High-Throughput Assay in Soluble Lysate for Prioritizing Protein Expression ConstructsTian-Yu, J.; Licht, S.; Pardee, G.; Bhat, A.; Cao, Y.; Gao, W.; Sangalang, E.; Zaror, I.Analytical Biochemistry, 2010, 399 (2), 276-283
High Affinity Human Antibodies to Human IL-4 Receptor.Stevens, S.; Huang, T. T. and others.Regeneron Pharmaceuticals, Inc., United States Patent No. 7,794,717
Neutralizing Determinants of IL-17 Receptor A and Antibodies That Bind Thereto.Tocker, J.; Mehlin, C.; Lim, A. C.Amgen Inc., United States Patent No. 7,767,206
Polynucleotides Encoding IL-17 Receptor A Antigen Binding Properties.Tocker, J.; Peschon, J. J.; Smothers, J. F.Amgen Inc., Unites States Patent No. 7,786,284
Antibodies to IL-6 and User Thereof.Garcia-Martinez, L. and others.Alder Biopharmaceuticals Inc., United States Patent Application 20100150829
Design and Generation of Human de Novo pIX Phage Display Libraries.Tsui, P. and others.Johnson & Johnson, Inc., United States Patent Application 20100021477
Antibodies to IL-6 and User Thereof.Garcia-Martinez, L. and others.Alder Biopharmaceuticals Inc., United States Patent Application 20100129357
Antibody Producing Non-human Mammals.Logtenberg, T.; Throsby, M.; Kramer, R. A.; Pinto, R. D.; de Kruif, C. A.; Houtzager, E.Merus B. V., United States Patent Application 20100146647
Antagonists of IL-6 to Prevent or Treat ThrombosisSmith, J. T. L.Alder Biopharmaceuticals Inc., United States Patent Application 20100143294
Universal Fibronectin Type III Binding-Domain LibrariesCappuccilli, G.; Crea, R.; Shen, R.; Hokanson, C. A.; Kirk, P. B.; Liston, D. R.ProtElix, Inc., United States Patent Application 20100152063
N-Glycans and Uses Thereof.Liu, C.; Xiang, J.; Yan, S.; Wang, P.; Tai, W. C.Eureka Therapeutics, Inc., United State Patent Application 20100081172
Antagonists of IL-6 to Prevent or Treat Cachexia, Weakness, Fatigue and/or FeverSmith, J. T. L.; Latham, J.; Litton, M. J.; Schatzman, R. C.Alder Biopharmaceuticals Inc., United States Patent Application 20100158859
Treatment and Diagnosis of Abnormal Bone Density with an Inhibitor of the Glypican-Sclerostin InteractionChan, A. B.A Chan Holding B. V., United States Patent Application 20100129378
Light Targeting Molecules and Uses ThereofWang, X.; Bailly, V.; Lugovskoy, A.; Farrington, G. K.; Graff, C.Biogen Idec MA Inc., United States Patent Application 20100119511
Engineered Anti-IL-13 Antibodies, Compositions, Methods and UsesSwanson, R. V. and others.Johnson & Johnson, United States Patent Application 20100111959
Modified Host Cells and Uses Thereof.Liu, C.; Xiang, J.; Yan, S.; Wang, P.; Tai, W. C.Eureka Therapeutics Inc., United States Patent Application 20100081195
Methods for Generating Host CellsLiu, C.; Xiang, J.; Yan, S.; Wang, P.; Tai, W. C.Eureka Therapeutics Inc., United States Patent Application 20100081150
Modified Glycoproteins and Uses Thereof.Liu, C.; Xiang, J.; Yan, S.; Wang, P.; Tai, W. C.Eureka Therapeutics Inc., United States Patent Application 20100081794
Immobilization and Application of Antigenic Carbohydrates to Detect Infective MicroorganismsBergwerff, A. A. and others.United States Patent Application 20100062416
Methods of Therapeutic Treatment of EyesArchambeau, G. J.; Wood, A. B.; Watson, R. L.Revalesio Corporation, United States Patent Application 20100028442
High Affinity Human Antibodies to Human IL-4 ReceptorStevens, S.; Huang, T. T.; Martin, J. H.; Fairhurst, J. L.; Rafique, A.; Torres, M.; Pobursky, K. J.; Leidich, R. W.; Windsor, J. A.; Mikulka, W. R.; Ahrens, D. M.; Shi, E.; Papadopoulos, N. J.Regeneron Pharmaceuticals, Inc., United States Patent Application 20100021476
Immobilization and Application of Antigenic Carbohydrates to Detect Infective Micro-organismsBergwerff, A. A.; van Eerden, E.; Nacken, P. J.; Gortemaker, B. G. M.; Wolbert, R. B. G.Inventor Organization unknown, United States Patent Application 20100062416
Multiplex Detection of Cell Surface Receptors or Immobilized AntigensCen, H.Leap Biosciences Corporation, United States Patent Application 20100062461
Antibody Producing Non-human MammalsHoutzager, E.; Pinto, R. D.; Logtenberg, T.; Throsby, M.Merus B. V., United States Patent Application 20100069614
Expression of Surrogate Light ChainsHorowitz, L.; Bhatt, R. R.Sea Lane Biotechnologies, United States Patent Application 20100330676
Methods of Modulating the Proliferation and Differentiation Potential of Stem Cells and Progenitor CellsKnoblich, J.; Schwamborn, J.Institut Fur Molekulare Biotechnologie GMBH, United States Patent Application 20100317563
Antagonist Antibodies of Protease Activated Receptor-1 (PAR-1)Luehrsen, K. R.GINRF, United States Patent Application 20100330090
High Affinity Human Antibodies to Human IL-4 ReceptorStevens, S. and others.Regeneron Pharmaceuticals, Inc., United States Patent Application 20100291107
Antibodies to IL-6 and Use ThereofGarcia-Martinez, L. and others.Alder Biopharmaceuticals Inc., United States Patent Application 20100290993
Antibodies Immunoreactive with Heregulin-Coupled HER3Keyt, B.; Kauvar, L. M. and others.Trellis Biosciences, United States Patent Application 20100310557
Combination Antibiotic and Antibody Therapy for the Treatment of Pseudomonas Aeruginosa InfectionBaer, M. and others.KaloBios Pharmaceuticals, Inc., United States Patent Application 20100272736
Antibodies to Human Programmed Death Receptor PD-1Carven, G. J. and others.Organon USA, Inc., c/o Merck, United States Patent Application 20100266617
Wnt Antagonists and their Use in the Diagnosis and Treatment of Wnt-Mediated DisordersErnst, J. A. and others.Genentech, Inc., United States Patent Application 20100266593
The Structure of SHH in Complex with HHIP Reveals a Recognition Role for the Shh Pseudo Active Site in SignalingBosanac, I.; Maun, H.R.; Scales, S.J.; Wen, X.; Lingel, A.; Bazan, J.F.; de Sauvage, F.J.; Hymowitz, S.G.; Lazarus, R.A.Nature Structural & Molecular Biology, 2009, 16 (7), 691 - 698.
Label-free Detection of Biomolecular Interactions Using BioLayer Interferometry for Kinetic Characterization.Concepcion, J and othersCombinatorial Chemistry and High Throughput Screening, 2009, 12, 791 - 800
Antibodies to Granulocyte-Macrophage Colony-Stimulating FactorBobbington, C. R.; Luehrsen, K.; Yarranton, G. T.Kalobios Pharmaceuticals, Inc., United States Patent Application 20090274706
Poxvirus Proteomics and Virus-Host Protein InteractionsVan Vliet, K.; Mohamed, M. R.; Zhang, L.; Villa, N. Y.; Werden, S. J.; Liu, J.; McFadden, G.Microbiology and Molecular Biology Reviews, 2009, 73 (4), 730-749
Structural Basis for Parathyroid Hormone-Related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-Selective PeptidesPioszak, A. A.; Parker, N. R.; Gardella, T. J.; Xu, H. E.Journal of Biological Chemistry, 2009, 284, 28382-28391
Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors - Insight into Heterotrimeric IL-1 Signaling ComplexesLingel, A.; Weiss, T. M.; Niebuhr, M.; Pan, B.; Appleton, B. A.; Wiesmann, C.; Bazan, J. F.; Fairbrother, W. J.Structure, 2009, 17 (10), 1398-1410
A Predictive High-Throughput Scale-Down Model of Monoclonal Antibody Production in CHO CellsLegmann, R.; Schreyer, H. B.; Combs, R. G.; McCormick, E. L.; Russon, A. P.; Rodgers, S. T.Biotechnology and Bioengineering, 2009, 104 (6), 1107-1120
Fluidics-Free Molecular Interactions Analysis.Witte, K.Genetic and Engineering News, 2009, July 1, 29 (13)
Who Needs Labels? Macromolecular Interaction Sans Labels.Perkel, J. M.Science, 2009, Sep. 19, 1561
Direct Optical Detection in Fragment-Based Screening.Proll, F.; Fechner, P.; Proll, G.Analytical and Bioanalytical Chemistry, 2009, 393, 1557 - 1562
A Global Benchmark Study Using Affinity-based Biosensors.Rich, R.L. and othersAnalytical Biochemistry, 2009, 386 (2), 194-216
Human Antibodies to Human Delta Like Ligand 4.Papadopoulos, N. J.; Martin, J. H.; Smith, E.; Noguera-Troise, I.; Thurston, G.Regeneron Pharmaceuticals Inc., United States Patent 7,534,868
Antibodies to the PcrV Antigen of Pseudomonas Aeruginosa.Bebbington, C. R.; Luehrsen, K.; Yarranton, G. T.; Baer, M.KaloBios Pharmaceuticals Inc., United States Patent Application 20090191186
Universal Fibronectin Type III Binding-Domain Libraries.Cappuccilli, G.; Crea, R.; Shen, R.; Hokanson, C. A.; Kirk, P. B.; Liston, D. R.ProtElix, Inc., United States Patent Application 20090176654
Human Antibodies to Human Delta Like Ligand 4.Papadopoulos, N. J.; Martin, J. H.; Smith, E.; Noguera-Troise, I.; Thurston, G.Regeneron Pharmaceuticals Inc., United States Patent Application 20090142354
Compositions that Bind Multiple Epitopes of IGF-1R.Glaser, S.; Demarest, S.; Miller, B. R.; Hariharan, K.; Ho, S.; Dong, J.; Lugovskoy, A. A.United States Patent Application 20090130105
Novel Rabbit Antibody Humanization Methods and Humanized Rabbit Antibodies.Kovacevich, B. R.; Latham, J.Alder Biopharmaceuticals Inc., United States Patent Application 20090104187
Label-free, Real-time Detection System for Molecular Interaction Analysis.Lotze, M. T.The University of Pittsburgh, United States Patent Application 20090147264
High Affinity Human Antibodies to Human Nerve Growth Factor.MacDonald, L.; Torres, R.; Morra, M. R.; Martin, J. H.; Reinhardt, J. C.Regeneron Pharmaceuticals Inc., United States Patent Application 20090041717
Antibodies to IL-6 and Use Thereof.Garcia-Martinez, L.; Jensen, A. E. C.; Olson, K.; Dutzar, B.; Ojala, E.; Kovacevich, B.; Latham, J.; Smith, J. T. L.Alder Biopharmaceuticals Inc., United States Patent Application 20090028784
Antibodies to TNF Alpha and Use Thereof.Olson, K.; Dutzar, B.; Jensen, A. E. C.; Garcia-Martinez, L.; Ojala, E.; Latham, J.Alder Biopharmaceuticals Inc., United States Patent Application 20090022659
Human Antibodies to Human Delta-like Ligand 4.Papadopoulos, N. J.; Martin, J. H.; Smith, E.; Noguera-Troise, I.; Thurston, G.Regeneron Pharmaceuticals, Inc., United States Patent Application 20090017035
Exploring Blocking Assays Using Octet, ProteOn, and Biacore Biosensors.Abdiche, Y. N.; Malashock, D. S.; Pinkerton, A; Pons, J.Analytical Biochemistry, 2009, 386(2), 172-180
Human Antibodies to Human Delta-like Ligand 4.Papadopoulos, N. J.; Martin, J. H.; Smith, E.; Noguera-Troise, I.; Thurston, G.Regeneron Pharmaceuticals, Inc., United States Patent 7,488,806
Novel Rabbit Antibody Humanization Methods and Humanized Rabbit AntibodiesKovacevich, B. R.; Latham, J.Alder Biopharmaceuticals Inc., United States Patent Application 20090238825
Novel Compositions and Methods for the Treatment of Immune Related Diseases Clark, H.; Eaton, D.; Gonzalez, L.; Grogan, J.; Hackney, J. A.; Harden, K.; Yu, X.Genentech, Inc., United States Patent Application 20090258013
Method of Treatment and Prophylaxis of Diseases Related to Amyloid Deposition Using IGMScuderi, J. R. P.; Safavi, A.; Langevin, M. G.Talecris Biotherapeutics, Inc., United States Patent Application 20090269359
Antagonists of IL-6 to Prevent or Treat Cachexia, Weakness, Fatigue and/or FeverSmith, J. T. L.; Schatzman, R. C.; Litton, M. J.; Latham, J.Alder Biopharmaceuticals Inc., United States Patent Application 20090291077
Antagonists of IL-6 to Raise Albumin and/or Lower CRPSmith, J. T. L.Alder Biopharmaceuticals Inc., United States Patent Application 20090291082
Antagonists of IL-6 to Prevent or Treat ThrombosisSmith, J. T. L.Alder Biopharmaceuticals Inc., United States Patent Application 20090291089
Antibodies to IL-6 and Use ThereofGarcia-Martinez, L. and othersAlder Biopharmaceuticals Inc., United States Patent Application 20090297436
Antibodies to IL-6 and Use ThereofGarcia-Martinez, L. and othersAlder Biopharmaceuticals Inc., United States Patent Application 20090297513
A Rapid Method for Determining Dynamic Binding Capacity of Resins for the Purification of Proteins.Do, T.; Ho, F.; Heidecker, B.; Witte, K.; Chang, L.; Lerner, L.Protein Expression and Purification, 2008, 60, 147-150
The Surface Protein TIGIT Suppresses T Cell Activation by Promoting the Generation of Mature Immunoregulatory Dendritic Cells.Yu, X.; Harden, K.; Gonzalez, L. C.; Francesco, M.; Chiang, E.; Irving, B.; Tom, I.; Ivelja, S.; Refino, C. J.; Clark, H.; Eaton, D.; Grogan, J. L.Nature Immunology, 2008, 10, 48-57
Advantages and Application of Label-free Detection Assays in Drug Screening.Cunningham, B. T.; Laing, L. G.Expert Opinion on Drug Discovery, 2008, 3(8), 891-901
Humaneered Anti-factor B Antibody.Emlen, W.; Holers, V. M.; Flynn, P.Taligen Therapeutics, Inc., United States Patent Application 20080299114
Antibodies to Lymphotoxin-Alpha.Adams, C. W.; Grogan, J. L.; Gurney, A. L.; McCutcheon, K.Genentech Inc., WIPO Patent Application No. WO2008063776.
Human Antibodies to Human Delta-like Ligand 4.Papadopoulos, N. J.; Martin, J. H.; Smith, E.; Noguera-Troise, I.; Thurston, G.Regeneron Pharmaceuticals, Inc., United States Patent Application 20080181899
High Affinity Human Antibodies to Human IL-4 Receptor.Stevens, S.; Huang, T. T.; Martin, J. H.; Farihurst, J. L.; Rafique, A.; Torres, M.; Pobursky, K. J.; Leidich, R. W.; Windsor, J. A.; Mikulka, W. R.; Ahrens, D. M.; Shi, E.; Papadopoulos, N. J.Regeneron Pharmaceuticals, Inc., United States Patent Application 20080160035
Probing the Binding Mechanism and Affinity of Tanezumab, a Recombinant Humanized Anti-NGF Monoclonal Antibody, Using a Repertoire of Biosensors.Abdiche, Y. N.; Malashock, D. S.; Pons, J.Protein Science, 2008, 17(8), 1326-1335
Determining Kinetics and Affinities of Protein Interactions Using a Parallel Real-time Label-free Biosensor, the Octet.Abdiche, Y.N.; Malashock, D. S.; Pinkerton, A; Pons, J.Analytical Biochemistry, 2008, 377(2), 209-217
WNT Antagonists and Their Use in the Diagnosis and Treatment of WNT-mediated Disorders.Ernest, J. A.; Polakis, P.; Rubinfeld, B.; Dealmeida, V. I.Genentech, Inc., United States Patent Application 20080299136
Detecting DNA: Getting and Begetting Cancer.Farkas, A. M.; Kilgore, T. M.; Lotze, M. T.Current Opinion in Investigational Drugs, 2007, 8, 981-986
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