Target Identification

 

Pall ForteBio systems are indispensable tools in the hunt for promising therapeutic targets.

Real-time binding data provide unique insights into the specific molecular interactions that regulate cellular processes. Importantly, these label-free binding data also can pinpoint aberrant molecular interactions that lead to the pathway dysregulation and, ultimately, to disease. The Dip and Read format of Pall ForteBio systems makes them uniquely suited to the study of diverse molecular interactions in the most challenging, real-world samples. The 96-well and 384-well plate configurations enable powerful structure/function investigations, including large kinetic screens of panels of structural variants.

Protein-Protein Interactions

Protein structure/function researchers choose Pall ForteBio systems whenever their experiments call for creativity, flexibility and detailed analysis of multiple structural variants. The comprehensive menu of biosensor surfaces enables straightforward immobilization of the most popular protein purification tags. A favorite application is precise kinetic characterization of wild-type interaction domains versus panels of mutants. View related articles.

Protein-DNA/RNA Interactions

Protein structure/function researchers choose Pall ForteBio systems whenever their experiments call for creativity, flexibility and detailed analysis of multiple structural variants. The comprehensive menu of biosensor surfaces enables straightforward immobilization of the most popular protein purification tags. A favorite application is precise kinetic characterization of wild-type interaction domains versus panels of mutants. View related articles.

Protein-Lipid Interactions

Structure/function studies of membrane-bound proteins and transmembrane receptors are difficult to perform using microfluidics-based SPR platforms. The Octet platform's Dip and Read architecture enables straightforward experimental designs incorporating liposomes, phospholipids, and lipid bilayer structures. View related articles.