Featured Highlights

 

NEW APPLICATION NOTE: INFLUENZA VACCINE TITER

Octet assays are a convenient alternative to the SRID assay for influenza titer determination. Faster and more accurate with a wider dynamic range, titer can be measured for both intact virus and virus-surface released HA protein.

NEW! READY BLI DETECTION KIT - RESIDUAL PROTEIN A

A simpler, faster alternative to ELISA with reduced hands-on time for those who require a sensitive and robust assay for measuring recombinant Protein A or MabSelect SuReTM impurities in bioprocess samples.

NEW APPLICATION NOTE: FCRN KINETICS

The Octet platform provides a fast and flexible alternative for measuring in vitro binding kinetics of FcRn-IgG interactions. Application Note 19 outlines best practices for obtaining precise, reliable results from FcRn binding assays.

NEW FAB2G BIOSENSORS

Perform rapid detection and analysis of Fab fragments and IgG with the new Anti-Human Fab-CH1 2nd Generation (FAB2G) Biosensor. Expect even better performance than original FAB Biosensor in baseline stability, signal, and regeneration capability.

NEW HIS1K BIOSENSORS

Anti-Penta-HIS (HIS1K) Biosensors come pre-immobilized with the highly specific Penta-His antibody for capture of His-tagged proteins in complex samples. HIS1K Biosensors are qualified for both quantitation and kinetic characterization assays.

ANTI-CHO HCP DETECTION KIT

Bypass tedious and labor-intensive ELISA for HCP assays. The new Anti-CHO HCP Detection Kit offers the broad HCP recognition of the Cygnus 3G antibody and the rapid workflow of the Octet systems for the best of both worlds.

NEW OCTET DATA ANALYSIS HT SOFTWARE

Octet Data Analysis HT software lets you analyze large epitope binning datasets in classical sandwich, in-tandem and premix formats in minutes! Append and overlay data to combine multiple experiments and assign antibodies in the panel into clusters or bins.

APPLICATION NOTE 17

The Octet platform provides a fast and flexible alternative for measuring in vitro binding kinetics of Fc-gamma receptor-IgG interactions. Application Note 17 outlines best practices for obtaining precise and reliable results from FcγR kinetic assays.

NEW OCTET K2 SYSTEM

The Octet K2 system delivers an exceptional value for small labs wanting the power of BLI detection technology. This research-friendly system lets you run sensitive kinetics experiments to measure binding interactions of large and small molecules.

APPLICATION NOTE 16

The Octet HTX system runs cross-competition assays in a few hours using in-tandem, classical sandwich or premix assay formats, letting you test multiple permutations. Our new Application Note reviews principles and best practices for developing these assays.

HIGH PRECISION STREPTAVIDIN (SAX) BIOSENSORS

The High Precision Streptavidin Biosensor was specifically developed and qualified for applications in downstream drug discovery and regulated environments with more stringent assay precision requirements.

APPLICATION NOTE 15

New report shows Protein A BLI assays for Mab quantitation provide comparable accuracy and precision to HPLC, with significant cost and time savings.

OCTET HTX SYSTEM

The Octet HTX system lets you quantitate 96 samples in 2 minutes, perform full-plate kinetic screening in minutes not hours, and complete epitope binning studies in days, not weeks. Tailor your assays for max throughput or sensitivity with simultaneous 8, 16, 32, 48 or 96 well reads.

WORLDWIDE WORKSHOPS

Join us for one of our worldwide workshops, coming to a city near you! Learn about the latest advances in label-free assays and applications from industry and academic experts in biomolecular research, biopharmaceutical development, and bioprocessing.

ANTI-FLAG BIOSENSORS

Pre-immobilized with Sigma's ANTI-FLAG® M2 antibody, the Anti-FLAG Biosensor enables direct quantitation and kinetic characterization of FLAG-tagged recombinant proteins with no chemical modification to the protein.

ANTI-HIS (HIS2) BIOSENSORS

The Anti-HIS (HIS2) Biosensor is pre-immobilized with the next generation high-affinity, high-specificity Anti-HIS antibody from Maine Biotechnology Services (MBS) for direct capture and quantitation of HIS-tagged proteins.

BIOPHARM PORTAL

The BioPharm Portal lets you stay current on the latest studies using ForteBio's Octet and BLItz systems, and browse the steady stream of scientific publications by specific biopharmaceutical application area.

PROTEIN L BIOSENSORS

Protein L biosensors provide a rapid, direct method for quantitating a broad set of kappa light chain-containing immunoglobulins, including whole molecules, FAb fragments and single chain variable fragments, from buffer, conditioned media or complex matrices. The recombinant Protein L, factory-immobilized onto the biosensor, recognizes a wider range of antibody classes than both Protein A and G, including IgG, IgM, IgA, IgE and IgD. The Protein L biosensor is especially useful for quantifying antibodies and antibody fragments from serum based culture because Protein L does not bind bovine immunoglobulins, which often contaminate serum supplements.

ANTI-HUMAN FAB-CH1 BIOSENSORS

The Anti-Human Fab-CH1 Biosensor binds specifically to the CH1 domain of human IgG, allowing quantitation and kinetic characterization of human Fab, F(ab')2, and IgGs with no recognition towards free light chains. It is qualified for both quantitation and kinetic applications, enabling scientists to quickly and easily detect and quantitate human Fab, F(ab')2, and IgG, or to capture them for affinity measurements with other analytes. Combined with the ease of use provided by the BLItz platform or the high throughput provided by the Octet systems, the Anti-Human Fab-CH1 Biosensor greatly accelerates laboratory workflows and reduces time to results. The biosensor can be easily regenerated using a 10 mM glycine solution at pH 1.7

OCTET 384 SERIES

ForteBio’s new Octet RED384 and Octet QK384 systems are designed for high-throughput, label-free biomolecular quantitation and kinetic characterization, with a large dynamic range for protein quantitation. Get accurate concentration, kinetic constants, and affinity data for protein-protein, small molecule-protein and other fast-binding interactions — all with Dip and Read simplicity. The Octet RED384 and QK384 systems are easy to set up and when used in conjunction with robotics, provide complete unattended operation for your assays. An advanced quantitation module enhances quantitation sensitivity to sub-ng/mL. With the lowest cost-per-data point, label-free quantitation and kinetics are available to more laboratories than ever before.

OCTET QKe SYSTEM

The Octet QKe system is an enhanced performance version of the first-generation Octet QK instrument. Two acquisition rate settings and a higher-performance spectrometer combine to provide greater sensitivity and wider dynamic range for quantitation and kinetic analysis. In addition, biosensor re-racking provides enhanced flexibility and operational cost savings for running assays.

Ni-NTA (NTA) BIOSENSORS

The new Ni-NTA biosensors enable direct quantitation of HIS-tagged proteins and their easy capture for subsequent kinetic analyses with binding partners.

Anti-GST (GST) Biosensors

Glutathione-S-transferase (GST) is commonly fused to recombinant proteins as a means of facilitating detection, purification and increasing solubility. The anti-GST biosensor consists of a high affinity anti-GST antibody pre-immobilized on a ForteBio biosensor. In conjunction with the Octet System, the anti-GST biosensor provides a rapid and label-free method for GST-tagged protein quantitation and kinetic analysis. The high specificity of the antibody-based biosensor enables direct analysis of GST analytes in crude lysates, column eluents, cell lysates and cell culture supernatants, serving as a time-saving alternative to traditional analytical methods.

BLItz System

BLItz performs label-free assays in a drop of sample. Determine protein presence, quantitate proteins, analyze binding kinetics and develop immunoassays with this compact personal assay system.

DIP & READ RESIDUAL PROTEIN A ASSAY KIT

The Dip and Read Residual Protein A Detection Kit contains biosensors and all the reagents required to quantitate Protein A, or biosimilars such as MabSelect SuRe, in column fractions. The Dip and Read Residual Protein A Detection Kit provides the sensitivity and accuracy needed for this critical test along with minimal hands-on time and an easy to use protocol.

AMINE REACTIVE SECOND-GENERATION (AR2G) BIOSENSORS

The AR2G biosensor is a newly engineered biocompatible surface matrix that delivers enhanced performance for kinetic assays compared to the original Amine Reactive (AR) biosensor for most proteins. AR2G routinely achieves greater signal intensity than the AR biosensor during both loading (immobilization of ligand) and association (detection of analyte) assay steps while delivering the same reliable kinetic values. A decrease in non-specific binding events to the AR2G surface compared to AR has also been demonstrated.

OCTET RED96 SYSTEM

ForteBio's new Octet RED96 system is a multi-functional, label-free, real-time analysis instrument. It is ideal for rapidly measuring concentration of proteins and other biomolecules, measuring kinetics and affinity, and screening protein-protein and protein-small molecule interactions. The Octet RED96 can be used for a wide range of analyses including IgG and other protein titer, bioprocess development, quality analysis, crude antibody screening, epitope binning/mapping, ligand binding assays, small molecule and fragment screening and analysis, elucidating cell signaling mechanisms and infectious disease monitoring. Replace your stodgy HPLC, ELISA and other single-purpose microfluidics instruments for a unique, cutting-edge, protein analysis system that accelerates and simplifies your work.

ANTI-PENTA-HIS (HIS) BIOSENSORS

The six-histidine or penta-histidine peptide tag (HIS-tag) is a common peptide tag fused to recombinant proteins during cloning. Many tools have been developed enabling the tag to be used for easy detection and purification of tagged proteins. The Anti-Penta-HIS biosensor, for use on the Octet system, now provides a rapid, label-free method for quantification of HIS-tagged proteins. This biosensor comes with the highly specific QIAGEN Penta-HIS antibody pre-immobilized on the surface and is ready to use for specific detection and quantitation of HIS-tagged proteins.