Octet RED384 and Octet QK384 Systems
 The Octet RED384 and Octet QK384 16-channel instruments complement current 8- channel products, while adding exciting new features. These enhancements provide higher levels of throughput, speed, and flexibility.
Currently, there is no label-free system available for researchers to perform protein quantitation on a 384-well plate in one hour, and kinetic screening and characterization on a 384-well plate in about two hours. Additionally, systems that have lower throughput are substantially more expensive than the Octet platform.
With the new Octet RED384 and Octet QK384 instruments, researchers can now obtain IgG titer of 96 samples in 20 minutes or 384 samples in 75 minutes.
Key Features
The affordably priced Octet RED384 and Octet QK384 instruments pack a serious punch, delivering popular features requested by researchers:
- 16-well simultaneous sampling
- 384-well and 96-well formats
- Two plate locations maximize throughput and improve workflow
- Automation friendliness allows multiple-plate assays in one run
- Biosensor re-racking allows maximum flexibility and operational cost savings
- Advanced software offers greater versatility in experimental design and data analysis
Kinetic analysis including association and dissociation of biomolecules can be performed on up to 384 samples in one 384-well plate. The biosensor, sample and reagent trays can be transferred to and from the Octet instrument by robots. Target ligands can be batch immobilized onto biosensors and returned to the biosensor tray for re-use in future experiments, thus extending the number of uses for each biosensor, preserving valuable ligand, and maximizing flexibility in experimental design.
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Figure 1: Concentration curves obtained on Octet RED384 for human IgG at 0.5 μg/mL to 2000 μg/mL using Protein A biosensors and two-minute incubation per well. |
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Figure 2: TNF-α binding from solution to anti-TNF-α antibody on Streptavidin biosensors on Octet QK384. Two-fold dilution series starting at 150 nM, 6 replicates at each concentration. Association and dissociation performed for 300 seconds each. |
Octet systems are currently used in a broad range of life science research, including drug discovery and development, antibody characterization, proteomics, and quality control in biopharmaceutical manufacturing. With the Octet QK384 and Octet RED384 instruments, unmet needs in high-throughput quantitation and kinetic characterization are fulfilled.
Literature References
References to ForteBio's products in published literature.
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