Due to their high detection sensitivity, wide dynamic range, and compatibility with complex animal-derived samples, Pall ForteBio systems offer a powerful alternative to ELISA for pharmacokinetic and pharmacodynamic studies.
ELISA assays are commonly used for quantitation of biotherapeutic drugs in complex matrices such as serum and plasma to establish pharmacokinetic properties. The limited dynamic range of ELISA necessitates routine dilution of high-concentration samples, particularly for toxicokinetic studies where mg/mL drug concentrations are common. The Octet® system's extended dynamic range reduces the need for sample dilution. View related articles.