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ForteBio Interactions Newsletter Biosensor photo

SPRING 2012    VOLUME 5    ISSUE 1


Protein Analysis Gets Personal

Sriram Kumaraswamy, Ph.D., Manager, Marketing,

Every once in a while a product comes along that both positively and permanently impacts how scientists get their work done. Numerous products for protein analysis and characterization have been introduced in the last decade, but very few are so dramatically enabling that they can completely change how researchers gain access to protein analysis tools. ForteBio brought label-free protein analysis out of its cocoon with highly parallel, Dip and Read simplicity, and has now advanced the field even further by enabling instantaneous, micro-volume protein analysis on its new BLItz system.

BLItz packs the power of label-free analysis into an easy to use personal assay system small enough to fit on the palm of your hand. BLItz lets you characterize your proteins right at your bench — no core lab necessary.

  • Determine protein presence/absence instantly
  • Analyze binding kinetics at your bench
  • Quantitate proteins in seconds
  • Develop immunoassays in minutes

You can easily measure affinity and association/dissociation rate constants for biomolecular interactions, test column fractions for presence of your protein of interest, check protein activity before starting a complex experiment, characterize proteins in cell lysates in their folded state or monitor protein expression.

Here are a few reasons why BLItz changes the protein analysis game.

  1. BLItz needs just a drop of sample — 4 µL
  2. BLItz is super easy to use — pipet a drop of sample, insert a biosensor, and read!
  3. BLItz is ready to use right out of the box — there is no complex set up, maintenance, operation or learning involved.
  4. BLItz is affordable — you can make it your own personal instrument.

If you regularly try to get time on a protein interactions analysis instrument in a neighboring lab or core facility, imagine the ease and convenience of having an instrument in your own lab — on your own bench. If you are a core facility looking to offer the best value for protein analysis to your customers, consider BLItz. If you are in a process development lab or protein expression group, imagine being able to check crude samples for specific concentration of your protein in just seconds. You can also check if your protein is folded correctly by doing a direct binding experiment with its binding partner. If you are a reagent development lab making high quality antibodies and other proteins, get to know your antibody better by measuring it on BLItz. And if you are an assay developer, you can find the best antibody binding pairs for ELISA through direct binding, real-time assays.

BLItz is brilliant at characterizing antibody, protein, peptide and oligo interactions. Performing label-free, real-time biomolecular binding analysis right at your bench, BLItz measures affinity constants and association/dissociation rate constants for protein-protein, antibody-antigen, peptide-protein, protein-oligo, protein-RNA, RNA-RNA and other biomolecular interactions.

Visit to learn more about BLItz. Click on the Try BLItz link to sign up for a demo in your lab. Once it arrives, you can use the model binding system supplied with the demo package to run experiments and get to know BLItz. But I must warn you — once you start using BLItz, you may never want to go back to your old ways again!

Pipetting a drop of sample into BLItz.

FIGURE 1: Drop. Read. Done! BLItz is simple to use.

Drop. Read. Done! BLItz is simple to use.

FIGURE 2: Pipetting a drop of sample into BLItz.


Inserting a biosensor into BLItz.

FIGURE 3: Inserting a biosensor into BLItz.

 Dedicated BLItz Pro software for data acquisition and data analysis.

FIGURE 4: Dedicated BLItz Pro software for data acquisition and data analysis.