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PCH Biosensor

The PCH biosensor is a high capacity three-dimensional chemistry comprised of a linear polycarboxylate hydrogel layer

PCH Biosensor

(Replaces COOH5) The PCH biosensor is a high capacity three-dimensional chemistry comprised of a linear polycarboxylate hydrogel layer. This biosensor contains a high number of carboxylic acid functional groups that allows a large amount of target to be coupled onto the surface. This enables analysis of interactions of fragments and small molecules or for targets that exhibit low binding activity. Amine coupling is the standard immobilization method for PCH and its coupling capacity is the highest of the carboxyl biosensors. This surface is also useful where a non-Dextran based hydrogel is desired.

Resources of PCH Biosensor

Application Note Commitment to Covalency : Kinetics of Irreversible Inhibitors on the Pioneer FE System

The principal role of assay groups in drug discovery is to provide reliable methods, analysis, and data for confident decision-making about series progression. Particular assays are chosen to differentiate between affinity, specificity, cellular action, and most important mechanism of action.

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Application Note Fragment Based Drug Discovery on Pioneer Systems Using Next Generation SPR Analysis

Fragment-based drug design (FBDD) has become an increasingly popular platform for the identification of lead candidates in drug discovery programs. The detection and characterization of fragment binding events is facilitated by sensitive biophysical technologies capable of detecting low-affinity interactions of low molecular weight compounds. Over the last decade approaches such as nuclear magnetic resonance (NMR), X-ray crystallography, differential scanning fluorimetry (DSF), and surface plasmon resonance (SPR) have become core technologies in many pharma

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Flyer SPR biosensor selection guide – Pioneer Systems

Read this document which is helpful in the selection of SPR Biosensor with their detail information.

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Flyer BLI Biosensors Selection Guide

Read this document which is helpful in the selection of Biosensor with their detail information.

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