A Stable IgG-like Bispecific Antibody Targeting the Epidermal Growth Factor Receptor and the Type I Insulin-like Growth Factor Receptor Demonstrates Superior Anti-Tumor Activity

Dong J., et al., 3(3), 273-88, Mabs, 2011

The epidermal growth factor receptor (EGFR) and the type I insulin-like growth factor receptor (IGF-1R) are two cell surface receptor tyrosine kinases known to cooperate to promote tumor progression. This publication reports on the development and characterization of a stable IgG-like bispecific antibody dual-targeting EGFR and IGF-1R. IGF-R1 binding assays were performed on the Octet RED platform. The biospecific antibody was captured on Anti-Human IgG Fc biosensors and incubated with different concentrations of the IGF-1R ectodomain.

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