An EGFR Targeting Nanoparticle Self Assembled from a Thermoresponsive Polymer

Goodall S, et al., doi: 10.1002/jctb.4509, J Chem Technol Biotechnol, 2014

The authors described a novel method of creating a self-assembled immunoparticle using a high affinity antibody scFv that is capable of targeting multiple receptors and delivering therapeutic antibody fragments and other therapeutic agents. The study demonstrates an assembly of a thermoresponsive polymer and a portion of the anti-EGFR into a nanoparticle with target specificity. Binding affinities were analyzed on the Octet system using HIS2 biosensors.

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