An Evaluation of the Capability of a Biolayer Interferometry Biosensor to Detect Low-molecular-weight Food Contaminants

McGrath, T F, et al., 405(8), 2535-44, Anal Bioanal Chem, 2013

The authors use the shellfish toxin domoic acid as a model compound to evaluate BLI for low-molecular weight food contaminant detection. Domoic acid was loaded onto Amine Reactive biosensors for analysis on the Octet RED96 system. A competition assay was developed in which the biosensor was dipped into solutions containing a fixed concentration of anti-domoic acid antibodies mixed with different concentrations of free domoic acid.

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