Heterogeneous IgG Interacts with FcRn and Its Transport Across Gastrointestinal Barrier

Qiao D, et al., doi:10.1080/09540105.2014.918588, Food Agric Immunol, 2014

In this report, the authors further examined the application of bovine colostrus and milk immunoglobulin as a passive immunity against diseases in other species, especially humans. The work demonstrated that heterogenous IgG could be transported into the blood by Fc receptors (FcRn) and that the IgGs posse various affinities for human FcRn. Binding assays were performed on the Octet RED system and Streptavidin biosensors were used.

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