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Identification of human neutralizing antibodies against MERS_CoV and their role in virus adaptive evolution

Tang XC, et al., 111(19):E2018-26., Proc Natl Acad Sci U S A., May 2014 In this report, the authors screened a human Ab-phage library using a novel panning strategy to identify seven neutralizing…


Evaluation of candidate vaccine approaches for MERS-CoV

Wang L, et al., 28;6:7712, Nature Communications, July 2015 The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a cause of severe respiratory disease highlights the need for…


Identification of a novel inhibitor against middle east respiratory syndrome Coronavirus Viruses

Sun Y, et al., 9(9). pii: E255, Viruses Sept. 2017 The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual…


Effects of Active Site Inhibitors on APN-dependent Coronavirus Entry

Y.Cai, University of Minnesota M.S. thesis. June 2017 Aminopeptidase N(APN) has been shown as a receptor of several coronaviruses, such as HCoV-229E, TGEV, CCoV and FeCoV. Bestatin and Actinonin are…


Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient

Niu P, et al., 218(8):1249-1260, Journal of Infectious Disease, Sept. 2018 Read More


Inhibition of Flaviviruses by Targetinga Conserved Pocket on the Viral Envelope Protein. Cell Chemical Biology

de Wispelaere M, et al., 25(8):1006-1016.e8, Cell Chemical Biology, Aug. 2018 Read More


Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV spike to avoid neutralization escape

Lingshu Wang, et al., 92(10). pii: e02002-17., Journal of Virology, April 2018 Read More


Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

Walls AC, et al., 176(5):1026-1039.e15., Cell Feb. 2019 Read More


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