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A Protein Engineering of Bacillus Thuringiensis δ-Endotoxin by Conjugating with 4"-O-succinoyl Abamectin

Pan Z, et al., 62, 211-6, Int J Biol Macromol, 2013 In this study, Bt toxin was conjugated with 4-O-succinoyl abamectin to construct a new biocide (BtA). The Octet RED system was used to investigate…


A Novel In Vitro Assay to Predict Neonatal Fc Receptor-Mediated Human IgG Half-Life

Souders C, et al., 7(5):912-21, MAbs, 2015 The neonatal Fc receptor (FcRn) binding to therapeutic IgG and the pH-dependence of this process had been investigated in depth. Using the BLI platform,…


A rapid method to quantitatively screen bispecific antibody using Protein A and His1K biosensors

Bispecific antibodies (bsAbs) were first reported by Nisonoff and Rivers in 19611 , however the engineering challenges associated with bsAbs have limited their development. Recent advances in…


Robust Quantitation Assay for Monoclonal Antibodies and Other Proteins on Octet Platform

The Octet platform provides analytical methods for measuring antibody and protein concentrations and binding affinities through various stages of drug discovery and development (Table 1). Octet…


Validated Quantitation and Activity Assay of Antibody Fragment Molecule (Fab) for Process Development and Quality Control

The group was able to develop a working Fab activity assay on the Octet RED system in less than a week. Relative to the overnight incubation and four-hour assay time of their ELISA protocol, the…


Biomolecular Binding Kinetics Assays on the Octet Platform

Direct measurement of biomolecular interactions plays an important role in biotherapeutic drug discovery and development. Label-Free analytical technologies such as the Octet® platform from Pall…


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