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Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization

Corroborating with advances in bispecific antibody research, BLI technology has proven to facilitate the characterization of these bispecific antibodies. In this example, Asokan et al.1 characterized…

High throughput screening of engineered bispecifics on Octet

More organizations are focusing on bispecifics as their therapeutic approach. Two bispecific antibodies are marketed and over 85 are in clinical development1. Bispecifics have been used for cancer…

Octet Platform: Increased Productivity and Publication for Lab

The key to increased productivity and publication for any laboratory

Octet Platform: Key to Increased Productivity and Publication for Laboratory

The key to increased productivity and publication for any new lab

Label-free detection: technologies, key considerations, and applications

Interactions between biomolecules serve as key triggers for many biological processes and, therefore, provide perfect targets for drug discoveries.

High Precision Streptavidin 2.0 (SAX2) Biosensors

Streptavidin-coated surfaces are widely used as a simple and straightforward method of molecular immobilization. Utilized with Bio-Layer Interferometry (BLI), Streptavidin biosensors enable quick and…

A detection and quantification label-free tool to speed up downstream processing of model mucins

Mucins detection Rapid selection of optimal lectin for mucin detection Among high molecular weight glycoproteins, mucins are thought to be potential candidates for the next generation of cancer…

Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138

Galctins binding to β-Galactosidase Differences in affinity of variants of Galactins to β-Galactosidase determined Galectins are Galactosidase binding proteins with one or two conserved carbohydrate…

Lectin bio-layer interferometry for assessing product quality of Fc- glycosylated immunoglobulin G

IgG Fucosylation and Galactosylation detection using Lectins Process induced differences in glycan content studied In another study, a BLI method was developed for the relative ranking of…

Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA

Affinity characterization of Mannose specific Lectins Affinity of lectins to glycan determined Mannose-specific lectins such as cyanovirin-N (CVN), microvin (MVN) and microcystis viridis lectin (MVL…

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