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Octet Platform: Key to Increased Productivity and Publication for Laboratory

The key to increased productivity and publication for any new lab

Label-free detection: technologies, key considerations, and applications

Interactions between biomolecules serve as key triggers for many biological processes and, therefore, provide perfect targets for drug discoveries.

High Precision Streptavidin 2.0 (SAX2) Biosensors

Streptavidin-coated surfaces are widely used as a simple and straightforward method of molecular immobilization. Utilized with Bio-Layer Interferometry (BLI), Streptavidin biosensors enable quick and…

A detection and quantification label-free tool to speed up downstream processing of model mucins

Mucins detection Rapid selection of optimal lectin for mucin detection Among high molecular weight glycoproteins, mucins are thought to be potential candidates for the next generation of cancer…

Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138

Galctins binding to β-Galactosidase Differences in affinity of variants of Galactins to β-Galactosidase determined Galectins are Galactosidase binding proteins with one or two conserved…

Lectin bio-layer interferometry for assessing product quality of Fc- glycosylated immunoglobulin G

IgG Fucosylation and Galactosylation detection using Lectins Process induced differences in glycan content studied In another study, a BLI method was developed for the relative ranking of…

Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA

Affinity characterization of Mannose specific Lectins Affinity of lectins to glycan determined Mannose-specific lectins such as cyanovirin-N (CVN), microvin (MVN) and microcystis viridis lectin…

High-throughput sialylation measurement using lectins on an Octet platform for clone screening

Sialylation detection and quantitation Crude samples analyzed for titer and sialylation in 60 minutes Good correlation with HPLC demonstrated The detection and determination of sialic acid…

Automating Octet Assays : ligand screening at Avitide

Drug development and production is challenging. Avitide, based in Lebanon, New Hampshire, provides on-demand development and supply of high-performance affinity purification resins for the…

Quality control of biotherapeutics using Octet systems

Bio-Layer Interferometry (BLI) has been rapidly adopted as an important analytical tool in laboratories that work with biological molecules, either as drug products, vaccines, or diagnostic reagents.

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