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The Structural Basis of DNA Binding by the Single-stranded DNA-binding Protein from Sulfolobus Solfataricus

Gamsjaeger R, et al., 465(2):337-46, Biochem J, 2015 Single-stranded DNA-binding proteins (SSBs) are a class of proteins that are present in all organisms. SSBs are known to have one or more…


Design, Synthesis, and Biological Evaluation of Novel FAK Scaffold Inhibitors Targeting the FAK-VEGFR3 Protein-protein Interaction

Gogate PN, et al., 80C:154-166, Eur J Med Chem., 2014 The authors designed, synthesized and screened for potent and selective tyrosine kinase inhibitors of focal adhesion kinase (FAK) and vascular…


Detection of Low-Affinity Anti-Drug Antibodies and Improved Drug Tolerance in Immunogenicity Testing by Octet Biolayer Interferometry

Li, J., et al., 54(2), 286-294, J Pharm Biomed Anal, 2010 The authors compare performance of the Octet system to ELISA and MSD techniques for detection of anti-drug antibodies (ADA) against an…


Towards a Universal Disulphide Stabilised Single Chain Fv Format: Importance of Interchain Disulphide Bond Location and vL-vH Orientation

Weatherill, E.E., et al., 25(7), 321-329, Protein Engineering, Design and Selection, 2012 Five disulphide bond locations were introduced into one scFv in order to compare their relative…


Conformational Stabilization of Ubiquitin Yields Potent and Selective Inhibitors of USP7

Zhang, Y, et al., 9(1), 51-8, Nat Chem Biol, 2013 Computational design along with phage display and affinity maturation were utilized to modify ubiquitin to select for variants with altered…


Detection of Deoxynivalenol using Biolayer Interferometry

Maragos, C.M., 27, 157-165, Mycotoxin Research, 2011 Deoxynivalenol (DON) is a toxin produced by Fusarium graminearum and F. culmorum. These fungi can infest wheat, barley, and corn and cause…


Efficient Production of Antibodies Against a Mammalian Integral Membrane Protein by Phage Display

Hotzel, I., et al., 24 (9), 679-689, Protein Engineering Design and Selection, 2011 The authors report on a phage display method for selecting antibody fragments specific for mammalian multispan…


Identification of Broadly Protective Human Antibodies to Pseudomonas Aeruginosa Exopolysaccharide Psl by Phenotypic Screening

Digiandomenico, A., et al., 209(7), 1273-87, J Experimental Medicine, 2012 Whole P. aeruginosa cells and single-chain variable fragment phage libraries derived from patients were employed to select…


A Small Molecule Focal Adhesion Kinase (FAK) Inhibitor, Targeting Y397 site: 1-(2-hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane; Bromide Effectively Inhibits FAK Autophosphorylation Activity and Decreases Cancer Cell

Golubovskaya, V.M., et al., 33(5), 1004-1013, Carcinogenesis, 2012 Y11 is a small molecule that was identified using computer modeling to target the main autophosphorylation site of FAK (Y397), a…


The Sclerostin-bone Protein Interactome

Devarajan-Ketha, H., et al., 417 (2), 830-835, Biochemical and Biophysical Research Communications, 2012 This publication identifies a large number of bone-derived protein binding partners of…


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